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Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium. , Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.
HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana. , Du K., Planta Med. August 1, 2015; 81 (12-13): 1154-62.
hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala. , De Mieri M., J Nat Prod. July 24, 2015; 78 (7): 1697-707.
Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. , Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.
Anesthetic drug midazolam inhibits cardiac human ether-à- go-go-related gene channels: mode of action. , Vonderlin N., Drug Des Devel Ther. February 16, 2015; 9 867-77.
High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance. , Steffensen AB., Sci Rep. January 12, 2015; 5 10009.
Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. , Cristofori-Armstrong B., Sci Rep. January 12, 2015; 5 14763.
Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites. , Choi SH., Mol Cells. September 1, 2014; 37 (9): 656-63.
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. , Lundby A., Nat Methods. August 1, 2014; 11 (8): 868-74.
A functional Kv1.2- hERG chimaeric channel expressed in Pichia pastoris. , Dhillon MS., Sci Rep. February 26, 2014; 4 4201.
Up-regulation of hERG K⁺ channels by B-RAF. , Pakladok T., PLoS One. January 1, 2014; 9 (1): e87457.
The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. , Lin TF., PLoS One. January 1, 2014; 9 (10): e110423.
AMP-activated protein kinase regulates hERG potassium channel. , Almilaji A., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.
C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. , Ng CA., PLoS One. October 4, 2013; 8 (10): e77032.
Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel. , Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels. , Cheng YM., J Gen Physiol. September 1, 2013; 142 (3): 289-303.
External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. , Kazmierczak M., J Gen Physiol. June 1, 2013; 141 (6): 721-35.
Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels. , de la Peña P., Biochem J. May 1, 2013; 451 (3): 463-74.
Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration. , Hong HK., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.
The eag domain regulates hERG channel inactivation gating via a direct interaction. , Gustina AS., J Gen Physiol. February 1, 2013; 141 (2): 229-41.
Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. , Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels. , Tan PS., J Gen Physiol. September 1, 2012; 140 (3): 293-306.
Identification and functional characterization of the novel human ether-a- go-go-related gene ( hERG) R744P mutant associated with hereditary long QT syndrome 2. , Aidery P., Biochem Biophys Res Commun. February 24, 2012; 418 (4): 830-5.
Stimulation of HERG channel activity by β-catenin. , Munoz C., PLoS One. January 1, 2012; 7 (8): e43353.
A molecular switch driving inactivation in the cardiac K+ channel HERG. , Köpfer DA., PLoS One. January 1, 2012; 7 (7): e41023.
Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration. , Lee BH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.
Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction. , Choi SH., Eur J Pharmacol. August 1, 2011; 663 (1-3): 59-67.
Differential effects of ginsenoside metabolites on HERG k channel currents. , Choi SH., J Ginseng Res. June 1, 2011; 35 (2): 191-9.
HERG channel inhibitors in extracts of Coptidis rhizoma. , Schramm A., Planta Med. May 1, 2011; 77 (7): 692-7.
hERG potassium channel gating is mediated by N- and C-terminal region interactions. , Gustina AS., J Gen Physiol. March 1, 2011; 137 (3): 315-25.
Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride. , Jo SH., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. , Es-Salah-Lamoureux Z., PLoS One. May 3, 2010; 5 (5): e10876.
Block of the human ether-a- go-go-related gene ( hERG) K+ channel by the antidepressant desipramine. , Hong HK., Biochem Biophys Res Commun. April 9, 2010; 394 (3): 536-41.
Inhibition of the human ether-a- go-go-related gene ( HERG) K+ channels by Lindera erythrocarpa. , Hong HK., J Korean Med Sci. December 1, 2009; 24 (6): 1089-98.
H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. , Jo SH., Pharmacol Res. November 1, 2009; 60 (5): 429-37.
Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine. , Hong HK., Korean J Physiol Pharmacol. June 1, 2009; 13 (3): 215-20.
Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. , Lee SY., PLoS Biol. March 3, 2009; 7 (3): e47.
Discovery of a novel activator of KCNQ1- KCNE1 K channel complexes. , Mruk K., PLoS One. January 1, 2009; 4 (1): e4236.
Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration. , Kim YJ., J Cardiovasc Pharmacol. December 1, 2008; 52 (6): 485-93.
A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope. , Christé G., Heart Rhythm. November 1, 2008; 5 (11): 1577-86.
[Analysis and analyzing mechanisms of HERG channel kinetics]. , Wang X ., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. October 1, 2008; 25 (5): 1068-73.
Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652. , Jo SH., Eur J Pharmacol. September 11, 2008; 592 (1-3): 19-25.
Blockade of the human ether-a- go-go-related gene potassium channel by ketanserin. , Tu DN., Sheng Li Xue Bao. August 25, 2008; 60 (4): 525-34.
An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. , Ma Z., J Gen Physiol. May 1, 2008; 131 (5): 483-502.
Protriptyline block of the human ether-à- go-go-related gene ( HERG) K+ channel. , Jo SH., Life Sci. January 30, 2008; 82 (5-6): 331-40.
Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function. , Grunnet M., Cell Physiol Biochem. January 1, 2008; 22 (5-6): 611-24.
Maprotiline block of the human ether-a- go-go-related gene ( HERG) K+ channel. , Jo SH., Arch Pharm Res. April 1, 2007; 30 (4): 453-60.
Structural requirements of human ether-a- go-go-related gene channels for block by bupivacaine. , Siebrands CC., Anesthesiology. March 1, 2007; 106 (3): 523-31.
Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine. , Kim MD ., Eur J Pharmacol. August 21, 2006; 544 (1-3): 82-90.
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform. , Scholz EP., Toxicol Lett. August 20, 2006; 165 (2): 156-66.