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Molecular Determinants for the High-Affinity Blockade of Human Ether-à-go-go-Related Gene K + Channel by Tolterodine. , Wang N., J Cardiovasc Pharmacol. November 1, 2022; 80 (5): 679-689.
Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer. , Levin M ., Cell. April 15, 2021;
The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts. , Shi YP ., Am J Physiol Heart Circ Physiol. August 1, 2020; 319 (2): H251-H261.
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. , Hull CM., Am J Physiol Regul Integr Comp Physiol. December 1, 2019; 317 (6): R921-R931.
The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C. , Park MH., Mol Cell Endocrinol. August 20, 2019; 494 110488.
Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG. , Vasseur L., Int J Mol Sci. June 28, 2019; 20 (13):
Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. , Furutani K., J Gen Physiol. February 4, 2019; 151 (2): 214-230.
Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice. , Li Y., J Med Chem. January 10, 2019; 62 (1): 159-173.
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. , Baburin I., Pharmacol Res. May 1, 2018; 131 150-163.
Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference. , Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2017; 390 (7): 701-710.
Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. , Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.
Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels. , Ng CA., J Biol Chem. September 12, 2014; 289 (37): 25822-32.
The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT. , Mechakra A., Gene. February 25, 2014; 536 (2): 348-56.
Acute and subacute effects of the selective serotonin-noradrenaline reuptake inhibitor duloxetine on cardiac hERG channels. , Fischer F., Naunyn Schmiedebergs Arch Pharmacol. September 1, 2013; 386 (9): 795-804.
Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels. , Perry MD ., J Gen Physiol. September 1, 2013; 142 (3): 275-88.
Blocking of the human ether-à- go-go-related gene channel by imatinib mesylate. , Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.
Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. , Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.
Molecular coupling in the human ether-a- go-go-related gene-1 ( hERG1) K+ channel inactivation pathway. , Ferrer T., J Biol Chem. November 11, 2011; 286 (45): 39091-9.
Strong activation of ether-à- go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells. , Schuster AM., Mol Pharmacol. November 1, 2011; 80 (5): 930-42.
Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells. , Crottès D., J Biol Chem. August 12, 2011; 286 (32): 27947-58.
hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. , Staudacher I., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels. , Larsen AP., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. , Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. , Gessner G., Eur J Pharmacol. April 25, 2010; 632 (1-3): 52-9.
Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT). , Eckey K., Cell Physiol Biochem. January 1, 2010; 26 (4-5): 503-12.
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/ NR2B N-methyl-D-aspartate receptors. , Mosley CA., Bioorg Med Chem. September 1, 2009; 17 (17): 6463-80.
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. , Scherer D., Br J Pharmacol. January 1, 2009; 156 (2): 226-36.
Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation. , Barrows B., Channels (Austin). January 1, 2009; 3 (4): 239-48.
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current. , Larsen AP., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin. , Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2008; 378 (1): 73-83.
Topological mapping of the asymmetric drug binding to the human ether-à- go-go-related gene product ( HERG) potassium channel by use of tandem dimers. , Myokai T., Mol Pharmacol. June 1, 2008; 73 (6): 1643-51.
Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide. , Lin C., Cardiology. January 1, 2008; 110 (3): 209-16.
Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. , Piper DR., Cell Physiol Biochem. January 1, 2008; 21 (1-3): 37-46.
Zebrafish model for human long QT syndrome. , Arnaout R., Proc Natl Acad Sci U S A. July 3, 2007; 104 (27): 11316-21.
Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure. , Watanabe E., Circ J. April 1, 2007; 71 (4): 471-8.
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform. , Scholz EP., Toxicol Lett. August 20, 2006; 165 (2): 156-66.
Involvement of Golgin-160 in cell surface transport of renal ROMK channel: co-expression of Golgin-160 increases ROMK currents. , Bundis F., Cell Physiol Biochem. January 1, 2006; 17 (1-2): 1-12.
Activation of human ether-a- go-go-related gene potassium channels by the diphenylurea 1,3- bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). , Hansen RS., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.
Expression and functional characterization of the human ether-à- go-go-related gene ( HERG) K+ channel cardiac splice variant in Xenopus laevis oocytes. , Aydar E., J Membr Biol. January 1, 2006; 211 (2): 115-26.
In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium. , Kim SW., Exp Mol Med. August 31, 2005; 37 (4): 269-75.
Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 423-35.
Block of wild-type and inactivation-deficient human ether-a- go-go-related gene K+ channels by halofantrine. , Sánchez-Chapula JA., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.
Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X). , Thomas D., Cardiovasc Res. December 1, 2004; 64 (3): 467-76.
Activation of cardiac human ether-a- go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors. , Thomas D., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.
Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome. , Zehelein J., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.
Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone. , Zitron E., Naunyn Schmiedebergs Arch Pharmacol. August 1, 2004; 370 (2): 146-56.
Inhibition of human ether-a- go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. , Thomas D., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.
Physicochemical features of the HERG channel drug binding site. , Fernandez D., J Biol Chem. March 12, 2004; 279 (11): 10120-7.
Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/ minK potassium channels. , Thomas D., Br J Pharmacol. November 1, 2003; 140 (5): 996-1002.
The antipsychotic drug chlorpromazine inhibits HERG potassium channels. , Thomas D., Br J Pharmacol. June 1, 2003; 139 (3): 567-74.