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Resection of DNA double-strand breaks activates Mre11- Rad50- Nbs1- and Rad9- Hus1- Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts. , Tatsukawa K., Nucleic Acids Res. April 12, 2024; 52 (6): 3146-3163.
Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1. , Colding-Christensen CS., Nat Commun. December 14, 2023; 14 (1): 8293.
MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks. , Montales K., PLoS One. August 2, 2022; 17 (8): e0271905.
The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase. , Tarcan Z., J Biol Chem. August 1, 2022; 298 (8): 102234.
Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system. , Montales K., Sci Rep. January 11, 2021; 11 (1): 467.
Kinesin Kif2C in regulation of DNA double strand break dynamics and repair. , Zhu S., Elife. January 17, 2020; 9
Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining. , Zhu S., Nucleic Acids Res. October 13, 2017; 45 (18): 10583-10594.
Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts. , Holden J., PLoS One. July 10, 2017; 12 (7): e0181131.
Xenopus Mcm10 is a CDK-substrate required for replication fork stability. , Chadha GS., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.
Non-homologous end joining repair in Xenopus egg extract. , Zhu S., Sci Rep. June 21, 2016; 6 27797.
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. , Chen C ., Proc Natl Acad Sci U S A. December 17, 2013; 110 (51): 20605-10.
APE2 is required for ATR- Chk1 checkpoint activation in response to oxidative stress. , Willis J., Proc Natl Acad Sci U S A. June 25, 2013; 110 (26): 10592-7.
The Mre11- Rad50- Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. , Lee J ., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.
A role for the MRN complex in ATR activation via TOPBP1 recruitment. , Duursma AM., Mol Cell. April 11, 2013; 50 (1): 116-22.
SUMO2/3 modification of cyclin E contributes to the control of replication origin firing. , Bonne-Andrea C., Nat Commun. January 1, 2013; 4 1850.
Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. , Lee EM ., DNA Repair (Amst). September 1, 2012; 11 (9): 741-52.
Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. , Sareen A., Nucleic Acids Res. September 1, 2012; 40 (17): 8425-39.
Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. , Kumar S ., Cell Cycle. March 15, 2012; 11 (6): 1183-94.
Essential roles of Xenopus TRF2 in telomere end protection and replication. , Muraki K., Genes Cells. June 1, 2011; 16 (6): 728-39.
Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts. , Le Breton C., PLoS One. April 15, 2011; 6 (4): e18554.
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. , Cosentino C., EMBO J. February 2, 2011; 30 (3): 546-55.
A new in vitro system for activating the cell cycle checkpoint. , Wang J ., Cell Cycle. February 1, 2011; 10 (3): 500-6.
CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. , Ramírez-Lugo JS., Cell Cycle. February 1, 2011; 10 (3): 469-80.
A novel role for greatwall kinase in recovery from DNA damage. , Peng A ., Cell Cycle. November 1, 2010; 9 (21): 4364-9.
Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. , Kundu LR., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.
Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/ Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. , Wawrousek KE., Cell Cycle. March 15, 2010; 9 (6): 1156-66.
Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. , Peng A ., Curr Biol. March 9, 2010; 20 (5): 387-96.
Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors. , Landais I., Mol Cancer. December 31, 2009; 8 133.
CtIP links DNA double-strand break sensing to resection. , You Z., Mol Cell. December 25, 2009; 36 (6): 954-69.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ ATM pathways. , Sobeck A., J Biol Chem. September 18, 2009; 284 (38): 25560-8.
Studying the DNA damage response using in vitro model systems. , Garner E., DNA Repair (Amst). September 2, 2009; 8 (9): 1025-37.
Responding to chromosomal breakage during M-phase: insights from a cell-free system. , Smith E., Cell Div. July 14, 2009; 4 15.
An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly. , Brown N., Cell Cycle. July 1, 2009; 8 (13): 1997-2001.
The Mre11- Rad50- Nbs1 complex mediates activation of TopBP1 by ATM. , Yoo HY., Mol Biol Cell. May 1, 2009; 20 (9): 2351-60.
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. , Smith E., Nat Cell Biol. March 1, 2009; 11 (3): 278-85.
DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. , Labit H., Nucleic Acids Res. October 1, 2008; 36 (17): 5623-34.
Mre11- Rad50- Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. , Jazayeri A., EMBO J. July 23, 2008; 27 (14): 1953-62.
Aven-dependent activation of ATM following DNA damage. , Guo JY., Curr Biol. July 8, 2008; 18 (13): 933-42.
Plx1 is required for chromosomal DNA replication under stressful conditions. , Trenz K., EMBO J. March 19, 2008; 27 (6): 876-85.
Rapid activation of ATM on DNA flanking double-strand breaks. , You Z., Nat Cell Biol. November 1, 2007; 9 (11): 1311-8.
Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos. , Peng A ., Mol Cell Biol. October 1, 2007; 27 (19): 6852-62.
Ataxia-telangiectasia mutated ( ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. , Yoo HY., J Biol Chem. June 15, 2007; 282 (24): 17501-6.
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. , Trenz K., EMBO J. April 19, 2006; 25 (8): 1764-74.
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. , Petersen P., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.
Phosphorylation of Chk1 by ATM- and Rad3-related ( ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. , Kim SM., J Biol Chem. November 18, 2005; 280 (46): 38355-64.
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. , You Z., Mol Cell Biol. July 1, 2005; 25 (13): 5363-79.
ATM and ATR check in on origins: a dynamic model for origin selection and activation. , Shechter D ., Cell Cycle. February 1, 2005; 4 (2): 235-8.
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. , Yoo HY., J Biol Chem. December 17, 2004; 279 (51): 53353-64.
Mre11 assembles linear DNA fragments into DNA damage signaling complexes. , Costanzo V., PLoS Biol. May 1, 2004; 2 (5): E110.
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. , Costanzo V., Mol Cell. January 1, 2003; 11 (1): 203-13.