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Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. , Kundu LR., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. , Yoshida K., J Cell Sci. January 15, 2010; 123 (Pt 2): 225-35.
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. , Lindsey-Boltz LA., J Biol Chem. November 27, 2009; 284 (48): 33107-14.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ ATM pathways. , Sobeck A., J Biol Chem. September 18, 2009; 284 (38): 25560-8.
An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly. , Brown N., Cell Cycle. July 1, 2009; 8 (13): 1997-2001.
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. , Smith E., Nat Cell Biol. March 1, 2009; 11 (3): 278-85.
DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. , Labit H., Nucleic Acids Res. October 1, 2008; 36 (17): 5623-34.
Probing ATR activation with model DNA templates. , Cimprich KA., Cell Cycle. October 1, 2007; 6 (19): 2348-54.
The Rad9- Hus1- Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. , Lee J , Lee J ., J Biol Chem. September 21, 2007; 282 (38): 28036-44.
Ataxia-telangiectasia mutated ( ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. , Yoo HY., J Biol Chem. June 15, 2007; 282 (24): 17501-6.
Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. , Lupardus PJ., Methods. February 1, 2007; 41 (2): 222-31.
Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. , Yan S ., J Cell Biol. April 24, 2006; 173 (2): 181-6.
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. , Trenz K., EMBO J. April 19, 2006; 25 (8): 1764-74.
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. , Lupardus PJ., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.
TopBP1 activates the ATR- ATRIP complex. , Kumagai A ., Cell. March 10, 2006; 124 (5): 943-55.
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. , Petersen P., Mol Cell Biol. March 1, 2006; 26 (5): 1997-2011.
Phosphorylation of Chk1 by ATM- and Rad3-related ( ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. , Kim SM., J Biol Chem. November 18, 2005; 280 (46): 38355-64.
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. , Byun TS., Genes Dev. May 1, 2005; 19 (9): 1040-52.
ATM and ATR check in on origins: a dynamic model for origin selection and activation. , Shechter D ., Cell Cycle. February 1, 2005; 4 (2): 235-8.
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. , Yoo HY., J Biol Chem. December 17, 2004; 279 (51): 53353-64.
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. , Luciani MG., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.
Claspin and the activated form of ATR- ATRIP collaborate in the activation of Chk1. , Kumagai A ., J Biol Chem. November 26, 2004; 279 (48): 49599-608.
Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint. , Marheineke K ., J Biol Chem. July 2, 2004; 279 (27): 28071-81.
Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. , Jeong SY., J Biol Chem. November 21, 2003; 278 (47): 46782-8.
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. , Lee J , Lee J ., Mol Cell. February 1, 2003; 11 (2): 329-40.
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. , Costanzo V., Mol Cell. January 1, 2003; 11 (1): 203-13.
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. , Lupardus PJ., Genes Dev. September 15, 2002; 16 (18): 2327-32.
Aphidicolin triggers a block to replication origin firing in Xenopus egg extracts. , Marheineke K ., J Biol Chem. May 18, 2001; 276 (20): 17092-100.
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. , Hekmat-Nejad M., Curr Biol. December 1, 2000; 10 (24): 1565-73.
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. , Guo Z., Genes Dev. November 1, 2000; 14 (21): 2745-56.