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Deep learning is widely applicable to phenotyping embryonic development and disease. , Naert T., Development. November 1, 2021; 148 (21):
Role of KLHL3 and dietary K+ in regulating KS- WNK1 expression. , Ostrosky-Frid M., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.
A novel homozygous mutation (p.N958K) of SLC12A3 in Gitelman syndrome is associated with endoplasmic reticulum stress. , Tang W., J Endocrinol Invest. March 1, 2021; 44 (3): 471-480.
Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome. , Greenberg RS., Cell. September 5, 2019; 178 (6): 1421-1436.e24.
Structure-function relationships in the renal NaCl cotransporter (NCC). , Moreno E., Curr Top Membr. January 1, 2019; 83 177-204.
The Many Faces of Xenopus: Xenopus laevis as a Model System to Study Wolf-Hirschhorn Syndrome. , Lasser M., Front Physiol. January 1, 2019; 10 817.
Kidney-specific WNK1 isoform (KS- WNK1) is a potent activator of WNK4 and NCC. , Argaiz ER., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.
The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4- SPAK Pathway. , Bazúa-Valenti S., J Am Soc Nephrol. July 1, 2018; 29 (7): 1838-1848.
Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney. , Zhang B., Development. March 22, 2018; 145 (6):
The European Eel NCCβ Gene Encodes a Thiazide-resistant Na-Cl Cotransporter. , Moreno E., J Biol Chem. October 21, 2016; 291 (43): 22472-22481.
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation. , Murthy M., Physiol Rep. July 1, 2016; 4 (13):
Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling. , Tutakhel OA., Am J Physiol Renal Physiol. February 1, 2016; 310 (3): F204-16.
WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. , Wang D., Nephron. January 1, 2016; 133 (4): 287-95.
TACC3 is a microtubule plus end-tracking protein that promotes axon elongation and also regulates microtubule plus end dynamics in multiple embryonic cell types. , Nwagbara BU ., Mol Biol Cell. November 1, 2014; 25 (21): 3350-62.
Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. , Cerqueira DM., Dev Biol. October 1, 2014; 394 (1): 54-64.
MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney. , Romaker D., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): 6335-40.
Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension. , Picard N., J Am Soc Nephrol. March 1, 2014; 25 (3): 511-22.
Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros. , Zhang B., Dev Biol. April 1, 2013; 376 (1): 31-42.
Calponin 2 acts as an effector of noncanonical Wnt-mediated cell polarization during neural crest cell migration. , Ulmer B., Cell Rep. March 28, 2013; 3 (3): 615-21.
Insulin increases the functional activity of the renal NaCl cotransporter. , Chávez-Canales M., J Hypertens. February 1, 2013; 31 (2): 303-11.
Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. , Rosenbaek LL., J Physiol. December 1, 2012; 590 (23): 6121-39.
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. , Castañeda-Bueno M., Proc Natl Acad Sci U S A. May 15, 2012; 109 (20): 7929-34.
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. , Oi K., Biol Open. February 15, 2012; 1 (2): 120-7.
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone- SGK1- Nedd4-2 pathway. , Arroyo JP., J Am Soc Nephrol. September 1, 2011; 22 (9): 1707-19.
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. , Liu Z., Hum Mol Genet. March 1, 2011; 20 (5): 855-66.
γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter. , Dimke H., J Am Soc Nephrol. March 1, 2011; 22 (3): 508-17.
Inversin relays Frizzled-8 signals to promote proximal pronephros development. , Lienkamp S ., Proc Natl Acad Sci U S A. November 23, 2010; 107 (47): 20388-93.
The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. , Glover M., Can J Physiol Pharmacol. October 1, 2010; 88 (10): 986-95.
Effects of dietary K on cell-surface expression of renal ion channels and transporters. , Frindt G., Am J Physiol Renal Physiol. October 1, 2010; 299 (4): F890-7.
Serotonin 2B receptor signaling is required for craniofacial morphogenesis and jaw joint formation in Xenopus. , Reisoli E., Development. September 1, 2010; 137 (17): 2927-37.
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. , Leviel F., J Clin Invest. May 1, 2010; 120 (5): 1627-35.
The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. , Tran U ., Development. April 1, 2010; 137 (7): 1107-16.
The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/ Lhx1. , Agrawal R ., Development. December 1, 2009; 136 (23): 3927-36.
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. , Rozansky DJ., J Clin Invest. September 1, 2009; 119 (9): 2601-12.
Organization of the pronephric kidney revealed by large-scale gene expression mapping. , Raciti D ., Genome Biol. January 1, 2008; 9 (5): R84.
Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway. , Ko B., Proc Natl Acad Sci U S A. December 11, 2007; 104 (50): 20120-5.
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. , Yang CL., J Clin Invest. November 1, 2007; 117 (11): 3403-11.
The prepattern transcription factor Irx3 directs nephron segment identity. , Reggiani L., Genes Dev. September 15, 2007; 21 (18): 2358-70.
Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros. , Tran U ., Dev Biol. July 1, 2007; 307 (1): 152-64.
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. , Jiang Y., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.
Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding. , Moreno E., J Biol Chem. June 23, 2006; 281 (25): 17266-75.
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 ( Kir1.1). , Leng Q., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. , Subramanya AR., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. , Rinehart J., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.
[WNK1 and WNK4, new players in salt and water homeostasis] , Hadchouel J., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.
Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line. , de Jong JC., Nephrol Dial Transplant. May 1, 2004; 19 (5): 1069-76.
A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity. , Moreno E., J Biol Chem. April 16, 2004; 279 (16): 16553-60.
WNK kinases regulate thiazide-sensitive Na-Cl cotransport. , Yang CL., J Clin Invest. April 1, 2003; 111 (7): 1039-45.
N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter. , Hoover RS., J Am Soc Nephrol. February 1, 2003; 14 (2): 271-82.
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. , Wilson FH., Proc Natl Acad Sci U S A. January 21, 2003; 100 (2): 680-4.