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Two adjacent phosphorylation sites in the C-terminus of the channel's α-subunit have opposing effects on epithelial sodium channel (ENaC) activity. , Diakov A., Pflugers Arch. July 1, 2022; 474 (7): 681-697.
Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane. , Cheung TT., Front Physiol. January 1, 2019; 10 7.
Regulation of Kv1.4 potassium channels by PKC and AMPK kinases. , Andersen MN., Channels (Austin). January 1, 2018; 12 (1): 34-44.
The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current. , Miranda P., J Neurosci. February 6, 2013; 33 (6): 2684-96.
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone- SGK1- Nedd4-2 pathway. , Arroyo JP., J Am Soc Nephrol. September 1, 2011; 22 (9): 1707-19.
The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. , Wesch D., Am J Physiol Cell Physiol. October 1, 2010; 299 (4): C779-90.
COMMD1 downregulates the epithelial sodium channel through Nedd4-2. , Ke Y., Am J Physiol Renal Physiol. June 1, 2010; 298 (6): F1445-56.
The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. , Böhmer C., Cell Physiol Biochem. January 1, 2010; 25 (6): 723-32.
60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. , Menniti M., Cell Physiol Biochem. January 1, 2010; 26 (4-5): 587-96.
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. , Rozansky DJ., J Clin Invest. September 1, 2009; 119 (9): 2601-12.
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. , Edinger RS., J Biol Chem. January 2, 2009; 284 (1): 150-157.
Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation. , Fakitsas P., J Am Soc Nephrol. April 1, 2007; 18 (4): 1084-92.
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. , Ring AM., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.
Renal Ca2+ handling in sgk1 knockout mice. , Sandulache D., Pflugers Arch. July 1, 2006; 452 (4): 444-52.
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase ( Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. , Rauh R., Pflugers Arch. June 1, 2006; 452 (3): 290-9.
Genomic profiling of mixer and Sox17beta targets during Xenopus endoderm development. , Dickinson K., Dev Dyn. February 1, 2006; 235 (2): 368-81.
SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells. , Alvarez de la Rosa D., Am J Physiol Cell Physiol. February 1, 2006; 290 (2): C492-8.
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells. , Flores SY., J Am Soc Nephrol. August 1, 2005; 16 (8): 2279-87.
Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. , Shumilina E., J Cell Physiol. July 1, 2005; 204 (1): 87-98.
An atlas of differential gene expression during early Xenopus embryogenesis. , Pollet N ., Mech Dev. March 1, 2005; 122 (3): 365-439.
Regulation of CLC-Ka/ barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. , Embark HM., Kidney Int. November 1, 2004; 66 (5): 1918-25.
SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes. , Zecevic M., Pflugers Arch. April 1, 2004; 448 (1): 29-35.
Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. , Yoo D., J Biol Chem. June 20, 2003; 278 (25): 23066-75.
Short-term aldosterone action on Na, K-ATPase surface expression: role of aldosterone-induced SGK1? , Verrey F., Ann N Y Acad Sci. April 1, 2003; 986 554-61.
SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells. , Verrey F., Cell Physiol Biochem. January 1, 2003; 13 (1): 21-8.
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. , Yun CC., J Am Soc Nephrol. December 1, 2002; 13 (12): 2823-30.
K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. , Gamper N., Pflugers Arch. October 1, 2002; 445 (1): 60-6.
Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase ( Sgk1) in Xenopus Oocytes. , Vuagniaux G., J Gen Physiol. August 1, 2002; 120 (2): 191-201.
Hypotonic induction of SGK1 and Na+ transport in A6 cells. , Rozansky DJ., Am J Physiol Renal Physiol. July 1, 2002; 283 (1): F105-13.
The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. , Bhargava A., Endocrinology. April 1, 2001; 142 (4): 1587-94.
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. , Loffing J., Am J Physiol Renal Physiol. April 1, 2001; 280 (4): F675-82.
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. , Wang J ., Am J Physiol Renal Physiol. February 1, 2001; 280 (2): F303-13.
Role of SGK in mineralocorticoid-regulated sodium transport. , Pearce D., Kidney Int. April 1, 2000; 57 (4): 1283-9.
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. , Shigaev A., Am J Physiol Renal Physiol. April 1, 2000; 278 (4): F613-9.
Epithelial sodium channel regulated by aldosterone-induced protein sgk. , Chen SY., Proc Natl Acad Sci U S A. March 2, 1999; 96 (5): 2514-9.