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Summary Anatomy Item Literature (3130) Expression Attributions Wiki
XB-ANAT-821

Papers associated with kidney (and wnk4)

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Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression., Ostrosky-Frid M., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.                    


Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis., Louis-Dit-Picard H., J Clin Invest. December 1, 2020; 130 (12): 6379-6394.


Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC., Argaiz ER., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.


ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation., Murthy M., Physiol Rep. July 1, 2016; 4 (13):             


WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination., Yu L., Am J Physiol Renal Physiol. July 1, 2013; 305 (1): F31-41.


A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo., Oi K., Biol Open. February 15, 2012; 1 (2): 120-7.              


WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              


The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4., Glover M., Can J Physiol Pharmacol. October 1, 2010; 88 (10): 986-95.


Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway., Rozansky DJ., J Clin Invest. September 1, 2009; 119 (9): 2601-12.


Renal and brain isoforms of WNK3 have opposite effects on NCCT expression., Glover M., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.


The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK., Murthy M., Biochem Biophys Res Commun. October 31, 2008; 375 (4): 651-4.


A novel protein kinase signaling pathway essential for blood pressure regulation in humans., Kahle KT., Trends Endocrinol Metab. April 1, 2008; 19 (3): 91-5.


Cotransporters, WNKs and hypertension: an update., Flatman PW., Curr Opin Nephrol Hypertens. March 1, 2008; 17 (2): 186-92.


The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex., Yang CL., J Clin Invest. November 1, 2007; 117 (11): 3403-11.


WNK4-mediated regulation of renal ion transport proteins., Peng JB., Am J Physiol Renal Physiol. October 1, 2007; 293 (4): F961-73.


Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families., Keszei AP., J Hypertens. October 1, 2007; 25 (10): 2074-81.


WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.


WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo., Ring AM., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4020-4.


An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis., Ring AM., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.


WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4., Jiang Y., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.


Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo., O'Reilly M., J Am Soc Nephrol. September 1, 2006; 17 (9): 2402-13.


WNK1 affects surface expression of the ROMK potassium channel independent of WNK4., Cope G., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.


WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)., Leng Q., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.


Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform., Subramanya AR., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.


WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis., Rinehart J., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.


WNK kinases and the control of blood pressure., Cope G., Pharmacol Ther. May 1, 2005; 106 (2): 221-31.


[WNK1 and WNK4, new players in salt and water homeostasis], Hadchouel J., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.


Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins., Yamauchi K., Proc Natl Acad Sci U S A. March 30, 2004; 101 (13): 4690-4.


WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia., Kahle KT., Proc Natl Acad Sci U S A. February 17, 2004; 101 (7): 2064-9.


WNK kinases regulate thiazide-sensitive Na-Cl cotransport., Yang CL., J Clin Invest. April 1, 2003; 111 (7): 1039-45.


Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Wilson FH., Proc Natl Acad Sci U S A. January 21, 2003; 100 (2): 680-4.

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