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Role of KLHL3 and dietary K+ in regulating KS- WNK1 expression. , Ostrosky-Frid M., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.
Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis. , Louis-Dit-Picard H., J Clin Invest. December 1, 2020; 130 (12): 6379-6394.
Kidney-specific WNK1 isoform (KS- WNK1) is a potent activator of WNK4 and NCC. , Argaiz ER., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation. , Murthy M., Physiol Rep. July 1, 2016; 4 (13):
WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. , Yu L., Am J Physiol Renal Physiol. July 1, 2013; 305 (1): F31-41.
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. , Oi K., Biol Open. February 15, 2012; 1 (2): 120-7.
WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. , Rinehart J., J Biol Chem. August 26, 2011; 286 (34): 30171-80.
The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. , Glover M., Can J Physiol Pharmacol. October 1, 2010; 88 (10): 986-95.
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. , Rozansky DJ., J Clin Invest. September 1, 2009; 119 (9): 2601-12.
Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. , Glover M., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.
The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK. , Murthy M., Biochem Biophys Res Commun. October 31, 2008; 375 (4): 651-4.
A novel protein kinase signaling pathway essential for blood pressure regulation in humans. , Kahle KT., Trends Endocrinol Metab. April 1, 2008; 19 (3): 91-5.
Cotransporters, WNKs and hypertension: an update. , Flatman PW., Curr Opin Nephrol Hypertens. March 1, 2008; 17 (2): 186-92.
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. , Yang CL., J Clin Invest. November 1, 2007; 117 (11): 3403-11.
WNK4-mediated regulation of renal ion transport proteins. , Peng JB., Am J Physiol Renal Physiol. October 1, 2007; 293 (4): F961-73.
Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families. , Keszei AP., J Hypertens. October 1, 2007; 25 (10): 2074-81.
WNK4 kinase is a negative regulator of K+-Cl- cotransporters. , Garzón-Muvdi T., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. , Ring AM., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4020-4.
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. , Ring AM., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. , Jiang Y., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. , O'Reilly M., J Am Soc Nephrol. September 1, 2006; 17 (9): 2402-13.
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. , Cope G., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 ( Kir1.1). , Leng Q., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. , Subramanya AR., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. , Rinehart J., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.
WNK kinases and the control of blood pressure. , Cope G., Pharmacol Ther. May 1, 2005; 106 (2): 221-31.
[WNK1 and WNK4, new players in salt and water homeostasis] , Hadchouel J., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. , Yamauchi K., Proc Natl Acad Sci U S A. March 30, 2004; 101 (13): 4690-4.
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. , Kahle KT., Proc Natl Acad Sci U S A. February 17, 2004; 101 (7): 2064-9.
WNK kinases regulate thiazide-sensitive Na-Cl cotransport. , Yang CL., J Clin Invest. April 1, 2003; 111 (7): 1039-45.
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. , Wilson FH., Proc Natl Acad Sci U S A. January 21, 2003; 100 (2): 680-4.