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G protein tyrosine kinase wnt Notch TGF/SMAD hedgehog  

cell biology: signal transduction via RTKs

--> schematic

= positive = negative

click on a molecule to obtain more information and references

mitogens

trophins

inflammatory

cytokines

stress
       
receptor tyrosine kinase

 

 
  • KHS1
  • HPK1
       
GRB2 GCK1   Rac/ cdc 42 PAK
GNRF MLK1-4  
ras   MEKK-X
MKK3/6
raf (MAPKKK) MEKK1-5   p38 abg
 
MEK (MAPKK) SEK 1/2
SAPK abg MAPKAPK2
MAPK
Elk1 c-Jun ATF-2 hsp27
p85 rsk
downstream genes

 

pathway data from Jim Woodget's site at the University of Toronto

Last update February 16, 2006

page administrator, Malcolm Whitman

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community gene expression genomics genetics atlas/movies/fate cell biology
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