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Figure 6. Timecourse of β-Catenin and Axin Concentrations Following a Transient Wnt StimulationTransient activation of the pathway is modeled assuming a Wnt stimulus that decays exponentially (Equation [6] with τW = 1/λ = 20 min) starting at t0 = 0. The straight line for t < 0 corresponds to the steady state before pathway stimulation. The curves are obtained by numerical integration of the differential equation system (see Dataset S1). The various curves for β-catenin and for axin differ in the turnover rate of axin determined by the parameters ν14 and k15 (curves a: reference values of these parameters; curves b: increase by a factor of 5; curves c: reduction by a factor of 5). All other parameters are given in the legend of Table 2. Image published in: Lee E et al. (2003) Copyright: © 2003 Lee et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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