Xenbase Image ID: 116343

Figure 7. Effects of Increasing Axin Concentration on β-Catenin Degradation(A) Effect of axin concentration on β-catenin half-life. Curve a: reference case (K18, K19 > 1 nM, ordered mechanism); curve b: K18 = 1 nM, K19 > 1 nM; curve c: K18 > 1 nM, K19 = 1 nM; curve d: K18 = 1 nM.(B) High concentration of axin inhibits β-catenin degradation in Xenopus egg extracts. Labeled β-catenin was incubated in Xenopus extracts in the absence (0 nM) or presence of moderate (10 nM) and high (300 nM) concentrations of axin. Moderate concentrations of axin greatly accelerate, whereas high concentrations inhibit β-catenin degradation. Image published in: Lee E et al. (2003) Copyright: © 2003 Lee et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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