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Figure 4. The Dorsal Animal Cap Is Required for Brain Formation(A) Ventral animal cap deletion (ΔV) produces a normal embryo.(B–F) Dorsal animal cap deletion (ΔD) results in loss of anterior brain structure. The headless phenotype of dorsal animal cap deletions was rescued by dorsal animal cap grafts (C) and animal pole grafts obtained from LiCl-treated embryos (E), but not by ventral animal cap transplants (D) or animal pole transplants (F). The average dorso-anterior indices (DAI) were 4.89 ([A] n = 28), 3.52 ([B] n = 25), 4.90 ([C] n = 10), 3.63 ([D] n = 19), 4.90 ([E] n = 12), and 3.50 ([F] n = 10).(G) Transplantation of the dorsal animal cap into the ventral animal cap region of a host embryo induced weak secondary axes (65.4%, n = 26). The embryo shown here was one of the strongest axes obtained.(H) Activity of BCNE transplanted ventrally was blocked by Chd-MO (n = 15). Image published in: Kuroda H et al. (2004) Copyright: © 2004 Kuroda et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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