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Figure 6. Cell Cycle Inhibiton by Xgadd-45γ Lipofection Affects Translation and Cell Fate(A–E) Retinal sections (st. 42) of control-lipofected retinas (A) or Xgadd-45γ–lipofected retinas (B–E). Xgadd-45γ lipofection decreases the size of lipofected cell clusters. (C–E) Show lipofected cells (GFP-traced) counterstained (arrowheads) with cell type markers: (C) ganglion cells (Fast Red mRNA detection of hermes), (D) horizontal cells (Fast Red mRNA detection of prox1), (E) cones (calbindin red immunodetection). ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cell layer.(F and G) Bars indicate the proportions of lipofected cells translating sensors (F). Bars showing the proportions of lipofected cell types at st. 42 are indicated by (G). Number of counted cells is indicated by n; single asterisk indicates p ≤ 0.05; double asterisk indicates p ≤ 0.01 (student's t-test); error bars: standard error of the mean. Image published in: Decembrini S et al. (2006) Copyright: © 2006 Decembrini et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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