Xenbase Image ID: 116977

Fig. 3. Missense mutation T226K induces loss of function of human Kv1.1 channels expressed in Xenopus oocytes. a–c Representative family of whole-oocyte currents recorded from oocytes expressing human Kv1.1-WT (a), Kv1.1-T226K (b), and both Kv1.1 WT and T226K (c). Currents were evoked by a series of 350-ms test pulses from −80 to +60 mV in 10-mV increments from a hold potential of −90 mV. Tail currents were recoded at −40 mV. Scale bar, 100 ms and 1 μA. d I–V curves for three experimental conditions in a–c. Data were collected for 10–15 oocytes in each group. The peak currents in a and c are significantly different at test voltages between 0 and +60 mV (P < 0.05) Image published in: Chen H et al. (2007) Image downloaded from an Open Access article in PubMed Central. © Springer-Verlag 2006 Larger Image Printer Friendly View

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