Xenbase Image ID: 117173

Figure 1. Schematic of Intestinal and Tail Cell Death and Cell Proliferation Events During Metamorphosis.Xenopus laevis metamorphosis begins when T3 levels elevate at stage 57 and terminates at stage 66 [26]. Top illustrations are of intestine cross-sections and are not to scale. Distances between stages are also not to scale. In response to T3 the intestine changes from a simple structure with one luminal fold (stage 56) to one with multiple folds in the post-metamorphic froglet following stage 66. As intestine metamorphosis begins ECM remodeling in the connective tissue (C) results in cell death (open circles) and cell proliferation (closed circles) of overlying epithelial cells (E). Bottom illustrations represent tail lengths during metamorphosis. Tail regression due to cell death begins at stage 62/63 and is complete by stage 66. Solid line = cell death, dashed line = cell proliferation. C = connective tissue, E = epithelial, M = muscle Image published in: Walsh LA et al. (2007) Walsh et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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