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Figure 5. Excess of General Hyperosmia(A) Histogram of average olfactory thresholds (adjusted for gender). The average threshold values for the four odorants were calculated for the raw data (black bars) and for data generated by 1,000 permutations of the individual odorant thresholds (dotted bars). The significantly broader distribution of the original data as compared to the permutated data (ANOVA, F = 1.83, p = 1.68 × 10−10) indicates an excess of individuals with extreme threshold values, particularly in the hypersensitivity end of the distribution.(B) Combinations of odorant thresholds (adjusted for gender) for the four odorants. Shown are hyperosmia (lowest 10% of thresholds in the entire sample, black), normosmia (middle 80%, gray), and hyposmia (highest 10%, white). Individuals with similar threshold patterns are clustered together. For clarity, only 50 of the total of 123 normosmic individuals are shown. The probability of observing three individuals defined as generally hyperosmic (i.e., having hyperosmia to all four odorants) in this cohort is computed as ∼10−12. Image published in: Menashe I et al. (2007) Copyright: © 2007 Menashe et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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