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Figure 1. Stoichiometry of Cl−/HCO3− exchange by slc26a3. (A) An example of a calibration of the Cl− electrode and that the resin is not sensitive to 90 mM HCO3− (green triangles) and is more selective for NO3− (black circles) than Cl− (red triangles). In B, control Xenopus oocytes (black traces) and an oocyte expressing AE1 (green traces) or slc26a3 (red traces) were bathed in HCO3−-buffered media, and, after the stabilization of pHi, they were incubated in Cl−-free media. The initial rates of pHi and Cli− changes were used to calculate the fluxes and the Cl−/HCO3− stoichiometry that are listed in Table 1. For simplicity, the changes in pHi and Cli− caused by exposure to CO2/HCO3− are shown only for the oocyte expressing slc26a3. In this and all other experiments, the traces shown are from representative experiments, and the number of experiments and means are given in the text. Image published in: Shcheynikov N et al. (2006) Copyright © 2006, The Rockefeller University Press. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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