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Figure 2. Coupling of Cl− and HCO3− transport by slc26a3. In A, an oocyte expressing slc26a3 was exposed to Cl−-free medium while incubated in HEPES-buffered and HCO3−-buffered media. Red trace, pHi; green trace, Cli−; black trace, membrane potential. In B, current generated by Cli−/OHo− and Cli−/HCO3o− exchange was measured in a control oocyte (black trace) and an oocyte expressing slc26a3 (blue trace) while holding the membrane potential at −90 mV. In C, an oocyte expressing slc26a3 and incubated in HCO3−-buffered media was exposed to Cl−-free medium at 10 min and was then exposed to different Clo− between 7.5 and 75 mM, as indicated by the bars, while measuring pHi (blue trace) or Cli− (green trace). The rates of pHi (squares) and Cli− (circles) changes from three experiments are summarized in D. Error bars represent SEM. Image published in: Shcheynikov N et al. (2006) Copyright © 2006, The Rockefeller University Press. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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