Xenbase Image ID: 118985

Figure 6. β-Catenin binding selectivity as a function of APC mutant status or GSK inhibition by LiCl. (A) A cytosolic fraction was prepared from colon carcinoma cell lines containing wild-type (HCT116) or mutant (HT29 and DLD1) forms of APC. (B) Selective binding activity of β-catenin in response to short-term, but not long-term treatment with LiCl. HEK293T cells were treated with 10 mM LiCl for 3, 6, and 15 h, after which cytosolic fractions were affinity precipitated as described above. Image published in: Gottardi CJ and Gumbiner BM (2004) Copyright © 2004, The Rockefeller University Press. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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