Xenbase Image ID: 118988

Figure 9. Multiple forms of β-catenin exist in cells. NH2-terminal phospho-β-catenin is well characterized and generated by the APC-Axin-GSK3β-CK1 complex (dashed line). Closed form of β-catenin is generated by Wnt signaling, perhaps through some of the same machinery (gray arrow). β-Catenin–α-catenin dimer is active for adhesion but not signaling. Open form binds both cadherin and TCF, and could explain how cadherin antagonizes β-catenin signaling in overexpression systems. The inactive form cannot participate in adhesion or signaling. Image published in: Gottardi CJ and Gumbiner BM (2004) Copyright © 2004, The Rockefeller University Press. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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