Xenbase Image ID: 120737

Figure 3. Slow inactivation of F1485Q channels in 10 and 150 mM [Na+]o. (A) Changes in peak current in response to changes in holding potential for two F1485Q-transfected cells bathed in either 150 (closed squares) or 10 mM Na+ (open circles). The cells were held at −140 mV for at least 10 min before the holding potential was sequentially changed every 5 min to −70, −140, +40, and −140 mV. Every 15 s during the entire protocol, a 20-ms recovery pulse to −140 mV was applied followed by a 20-ms test pulse to +60 mV (inset). The normalized peak current at +60 mV is plotted. (B) Current levels after 5 min at either −70 or +40 mV expressed as percent of the maximal current at a −140 mV holding potential. (C) 10–90% decay times for entry into slow inactivation at −70 and +40 mV. The 10–90% time corresponds to the time it takes for the current to decay from 10 to 90% of the maximal decay measured after 5 min at either −70 or +40 mV. (D) 10–90% times for recovery at −140 mV after 5 min of inactivation at either −70 mV or +40 mV. Numbers in parentheses are number of cells. Image published in: Townsend C and Horn R (1997) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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