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Figure 5. Single-channel data analysis. (A) Ensemble averages obtained from a two-channel outside-out patch successively bathed in 150, 10, and 150 mM Na+. Currents were activated by 90-ms pulses to +60 mV from a holding potential of −140 mV with a frequency of 0.5 Hz (n = 200 depolarizations for each bath solution). (B) Effects of [Na+]o on open time distributions. The normalized square root of the number of events per bin (n1/2) is plotted versus the logarithm of the open duration. The lines represent fits to single exponential distributions. Mean open times were 1.12 ± 0.03, 0.63 ± 0.01, and 0.93 ± 0.03 ms for 150, 10, and 150 mM Na+, respectively. Data from the two-channel patch shown in A. (C) Normalized first latency distributions, corrected for the number of channels, obtained for the same patch. (D) Cumulative distributions of the duration of the last (truncated) closing in a 90-ms depolarization for the same patch. (E and F) Cumulative distributions of the truncated closed time conditional on whether the following record contains openings (solid line) or not (dotted line) for a single-channel patch successively bathed in 10 (E) and 150 mM Na+ (F). Image published in: Townsend C and Horn R (1997) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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