XB-IMG-122650
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Figure 12. Spring effect of the AC region in channel gating. In the absence of bound Ca2+ and in the closed conformation, the AC region adopts a conformation that inhibits channel opening. Ca2+ binding (+Ca2+) or channel opening by depolarization (+V) removes this inhibition, rendering the channel gate more favorable to the open conformation. In the open conformation or when the Ca2+ binding sites are occupied, the AC region has little effect on channel gating. Image published in: Krishnamoorthy G et al. (2005) Copyright © 2005, The Rockefeller University Press. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |