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Figure 7. Model for the strand-specific processing of DNA ends. (A) End processing in the nucleoplasmic extract. xWRN (and potentially other helicases) are recruited to unwind the end in an ATP-dependent reaction. xDNA2 (and another exonuclease(s)) degrades the 5′ ss-tail. Proteins like MRE11 and CtIP (not depicted) might act upstream of xWRN. (B) The postulated RecQ-RecJ mechanism for end processing. Image published in: Liao S et al. (2008) © 2008 The Author(s). This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View |