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Figure 3. Activation of macroscopic TRPM2 currents requires micromolar [Ca2+]i. (A) Macroscopic TRPM2 current from an inside-out patch superfused with 32 µM ADPR and various test [Ca2+]i, bracketed by exposures to 125 µM Ca2+ (bars). Pipette [Ca2+] was ∼4 µM. (B) Mean currents in test [Ca2+]i, normalized to the mean of the currents in bracketing 125-µM Ca2+ segments, were plotted against [Ca2+]i and fitted to the Hill equation. Pipette [Ca2+] was either ∼4 µM (closed circles and solid fit line) or 1 mM (open circles and dashed fit line). Data are represented as mean ± SEM. Image published in: Csanády L and Törocsik B (2009) © 2009 Csanády and Törőcsik. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |