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Figure 7. Depolarization removes the gating effect of extracellular Ca2+ by preventing Ca2+ influx through the open pore. (A and B) In the presence of 32 µM ADPR macroscopic TRPM2 currents at various test potentials (bars below traces) were activated by exposure to 125 µM of intracellular Ca2+ and closed by its sudden removal. Colored smooth lines are fitted single exponentials and time constants are in milliseconds. Pipette [Ca2+] was ∼4 µM in A and 1 mM in B. (C) Closing rates (mean ± SEM) in zero [Ca2+]i and ∼4 µM (black circles) or 1 mM (red circles)of free Ca2+ in the pipette solution, obtained as the reciprocals of current decay time constants (see A and B, respectively), are plotted against membrane potential. Image published in: Csanády L and Törocsik B (2009) © 2009 Csanády and Törőcsik. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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