Xenbase Image ID: 124233

FIGURE 9. The binding of DIDS to the open conformation of MCT1. The figure shows a side (A) and top (B) view of the extracellular part of the open MCT1 model. The color scheme is the same as that in Fig. 7, except that DIDS is colored according to atom type with the carbon atoms colored gray. The figure shows how one isothiocyanate group of DIDS is in close contact with Lys38, whereas the two sulfonate groups are bound to Lys45, Lys282, and Lys413. The inset in B shows the numbering of the TM helices in this view. Image published in: Wilson MC et al. (2009) © 2009 by The American Society for Biochemistry and Molecular Biology, Inc. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View

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