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Figure 7. Voltage dependence of intracellular and extracellular PhTx block at saturating and subsaturating cGMP concentrations. (A) Normalized current transients elicited by stepping membrane voltage from −80 to 120 mV in the absence (top) or presence (bottom) of 0.3 µM of intracellular PhTx and of 2 mM (black) or 20 µM cGMP (blue; average of 20 consecutive traces from the same patch). The current in 20 µM cGMP is sevenfold smaller than that in 2 mM. (B) Normalized current transients, elicited by stepping membrane voltage from 120 to −80 mV, in the presence of 0.3 µM of intracellular PhTx and of 2 mM (black; average of five consecutive traces from the same patch) or 20 µM cGMP (blue; average of 10 consecutive traces from the same patch). (C) Normalized current transients elicited by stepping membrane voltage from 100 to −150 mV in the presence of 0.1 µM of extracellular PhTx and of 2 mM (black) or 20 µM cGMP (blue; average of 20 consecutive traces from the same patch). (D) Normalized current transients elicited by stepping membrane voltage from −200 to −50 mV in the presence of 0.1 µM of intracellular PhTx and of 2 mM (black) or 20 µM cGMP (blue; average of 20 consecutive traces from the same patch). Image published in: Martínez-François JR and Lu Z (2010) © 2010 Martínez-François and Lu. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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