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Figure 12. CNGA1 block by intracellular bis-QAC10 in 65 and 130 mM of symmetrical Na+. (A) The fraction of current not blocked (mean ± SEM; n = 4–7) in the presence of 65 mM (open symbols) and 130 mM (filled symbols) of symmetrical Na+ by 5 mM (black symbols) and 25 mM (blue symbols) bis-QAC10 is plotted against voltage. Curves were obtained by fitting Eq. 10 to the four datasets simultaneously. The resulting parameters are listed in Table I. (B) Data in A scaled to unity at −150 mV. Curves were obtained by fitting Eq. 7 to the four datasets simultaneously. The best-fit parameters were: KB = 7.97 ± 0.31 × 10−4 M, KB-Na = 8.97 ± 0.16 × 10−2, and Z = 1.00 ± 0.01. Image published in: Martínez-François JR and Lu Z (2010) © 2010 Martínez-François and Lu. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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