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Figure 3. Aberrant Pitx2 expression in a Vangl1gt/gt homozygous embryo.(A, B) Wild-type embryos with 7 somites (A, B, B') have Pitx2 expressed in the left lateral plate mesoderm (LPM). (C, D) A Vangl1gt/gt homozygous embryo with 8 somites has Pitx2 expressed bilaterally but predominant expression is in the right LPM. (D') Somites of the Vangl1gt/gt homozygous mutant are narrow and compressed in the anterior-posterior direction, in comparison to the wild-type embryo (B'). The mis-expression of Pitx2 and the turning defect suggest that Vangl1 might regulate L-R asymmetry establishment in the mouse ventral node. (B') and (D') are the boxed regions from (B) and (D) and are at the same magnification. Image published in: Antic D et al. (2010) Antic et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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