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Figure 2. Verapamil reduces short-circuit (Isc) level in H441 monolayers in a dose-dependent manner. (A) Representative Isc trace showing applications of a series of concentrations. Amiloride-sensitive Isc level (AS Ibasalsc) is the sum of verapamil-inhibitable and residual amiloride-sensitive fractions. (B) Normalized AS Isc levels (AS Iverasc/AS Ibasalsc) at each concentration were plotted as a dose-response curve. n = 6. The raw data were fitted with the Hill equation. IC50 value, 294.2 μM. (C) & (D) Verapamil on amiloride-insensitive Isc levels in amiloride pretreated cells. Representative trace (C) and corresponding average Isc levels before (Control) and after addition of amiloride and verapamil (D). n = 3. P = 0.89 for the Isc levels before and after verapamil. Paired t-test. Image published in: Han DY et al. (2010) Copyright ©2010 Han et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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