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Figure 3. Effects of CCB compounds on transepithelial short-circuit currents (Isc) in intact H441 monolayers. (A-C) Typical traces. 200 μM nifedipine (A), 10 μM bepridil (B) or 50 μM diltiazem (C) was added to the basolateral compartment followed by verapamil. Amiloride (100 μM, apical side) was finally applied to inhibit residual amiloride-sensitive currents. Arrows show the time point of addition. Total AS Isc is the difference between the Isc level before CCB and the amiloride-insensitive fraction, as indicated by a pair of vertical arrows. (D) CCB-sensitive fraction: CCB-inhibitable Isc/total AS Isc. One-way ANOVA. *P < 0.05 vs Verapamil. n = 3-10. Image published in: Han DY et al. (2010) Copyright ©2010 Han et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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