Xenbase Image ID: 125030

Figure 6. K+ channel blockers alter the inhibitory effects of verapamil in H441 cells. (A) Typical Isc traces showing the application of 100 μM verapamil alone (control), 100 μM clofilium (KV inhibitor), 20 μM tram34 (KCa3.1 inhibitor), and 100 μM glibenclamide (KATP inhibitor), respectively. These K+ channel blockers were applied to basolateral side followed by verapamil and amiloride (apical side) to compute total AS Isc. (B) Summary of average AS Isc levels. Paired t-test. *P < 0.05, **P < 0.01, *** P < 0.001 for comparison of pre- and post exposure of CCB. n = 4-17. (C) Reduced percentages of AS Isc levels by verapamil in H441 cells with and without pretreatment of K+ channel blockers. Two-sample, two-tailed t-test. *P < 0.05 vs Control. n = 4-17. Image published in: Han DY et al. (2010) Copyright ©2010 Han et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page