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Figure 7. Stimulatory effects of K+ channel openers subsequent to verapamil in H441 monolayers. (A) Representative traces showing response to a set of K+ channel openers from 1 μM to 1 mM in the presence of verapamil. (B) Corresponding concentration-response curves. The raw data were fitted with the Hill equation and the EC50 were 2.4, 391.8, and 1.2 μM, respectively, for pyrithione-Na, 1-EBIO, and minoxidil. (C) Summary of AS Isc levels before (Basal) and after verapamil (Verapamil) and K+ channel openers (10 μM Pyrithione-Na, 600 μM 1-EBIO, 10 μM Minoxidil). Paired t-test. *P < 0.05, **P < 0.01 for comparison of before and after K+ channel openers. n = 3-6. Image published in: Han DY et al. (2010) Copyright ©2010 Han et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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