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Figure 10. Verapamil inhibits ionophore-induced Ca2+ mobilization. Transient Ca2+ signal evoked by ionomycin was measured as relative fluorescent intensity with Fluo 4AM dye in real time with paired manner, in both control and verapamil incubated H441 cells. (A) Original traces showing on-time Ca2+ signal digitized in control (red) and verapamil exposed cells (green). (B) Maximal relative change in fluorescent intensity (Fpeak/F0). Nonparametric Mann-Whitney U-test. *P < 0.05 vs Control. n = 3. (C) The time to reach peak signal. Nonparametric Mann-Whitney U-test. *P < 0.05 Image published in: Han DY et al. (2010) Copyright ©2010 Han et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |