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Figure 3. Kinetics of Kir6.2/SUR1 and Kir6.2-G334D/SUR1 channels. (A) Single Kir6.2/SUR1 currents recorded at −60 mV in nucleotide-free solution. c, the closed current level. (B) Distributions of Kir6.2/SUR1 open times (left), closed times (middle), and burst times (right) in nucleotide-free solution. The PO(0) of the channel illustrated was 0.36. The distributions were fit with the following parameters. Open times: τO = 3.39 ms (τO,COR = 2.46 ms); closed times: τC1 = 0.44 ms, aC1 = 0.949; τC2 = 9.6 ms, aC2 = 0.022; τC3 = 53 ms, aC3 = 0.020; τC4 = 363 ms, aC4 = 0.009; burst times: τB1 = 93 ms, aB1 = 0.526, τB2 = 31 ms, aB2 = 0.328, τB3 = 1.7 ms, aB3 = 0.145. The mean burst duration (τB) was 59.3 ms. (C) Single Kir6.2-G334D/SUR1 currents recorded at −60 mV in nucleotide-free solution. c, the closed current level. (D) Distributions of Kir6.2-G334D/SUR1 open times (left), closed times (middle), and burst times (right) in nucleotide-free solution. The PO(0) of the channel illustrated was 0.27. The distributions were fit with the following parameters. Open times: τO = 3.32 ms (τO,COR = 2.32 ms); closed times: τC1 = 0.39 ms, aC1 = 0.940; τC2 = 16.9 ms, aC2 = 0.030; τC3 = 139 ms, aC3 = 0.023; τC4 = 415 ms, aC4 = 0.007; burst times: τB1 = 61 ms, a1 = 0.651; τB2 = 20 ms, a2 = 0.187; τB3 = 1.0 ms, a3 = 0.162. The mean burst duration (τB) was 43.6 ms. Image published in: Proks P et al. (2010) © 2010 Proks et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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