Xenbase Image ID: 125296

Figure 4. Rundown and reactivation of Kir6.2-G334D/SUR1 channels by MgATP and MgADP. (A) Representative record showing repetitive activation of Kir6.2-G334D/SUR1 current by 10 mM MgATP. Nucleotide application is indicated by the bars. Patch excision and the start of the perfusion with nucleotide-free solution are indicated by the arrows. The dotted line indicates the zero current level. (B–D) Estimates of NrPO (B), PO (C), and the fraction of functional channels (N) (D) calculated from noise analysis of current records obtained during repetitive application of 10 mM MgATP (open circles) or 1 mM MgADP (open squares), or in control solution before the application of nucleotide (open triangles). Data are mean ± SEM from 10 patches. The lines are drawn by eye. Image published in: Proks P et al. (2010) © 2010 Proks et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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