Xenbase Image ID: 1253

Fig. 1. Sox8 expression in neural crest progenitors and their derivatives. (A) Sox8 is first detected at the gastrula stage in a ventrolateral domain around the blastopore. At stage 11.5 (B-D) Sox8 expression around the blastopore persists and additional expression is detected lateral to the neural plate (arrows). Vegetal (A), lateral (B,C; anterior towards right) and dorsal (D; anterior towards the top) views. Comparison of Sox8 (E) Sox9 (F) and Sox10 (G) expression in sibling stage 14/15 embryos illustrates that all three genes are expressed in the presumptive neural crest. Dorsal views, anterior towards the top. (H) Section of a stage 15 embryo illustrates the expression of Sox8 in both the lateral (arrows) and the medial neural crest (arrowheads). At stage 17 (I,J), Sox8 persists in the neural crest region and is also expressed anterior to the neural plate in the prospective cement gland (arrow). As the neural tube closes (K,L), Sox8 is detected in the migrating neural crest cells in the cranial region (arrows), and the premigratory cells in the trunk neural crest (arrowheads). Dorsal view, anterior towards top (I,K); lateral view, anterior towards the left (L); cranial view (J). (M) Comparison of Sox8, Sox9 and Sox10 expression at the tailbud stages. Dorsal views of stage 25 embryos, anterior towards the right. Sox8, Sox9 and Sox10 are co-expressed in the migrating cranial neural crest. Posteriorly, although Sox8 and Sox10 are both expressed in trunk neural crest cells, Sox9 is downregulated in this cell population. At stage 35 (left panels, lateral views), Sox8 is detected in the cranial neural crest similar to Sox9; however, at this stage, Sox10 starts to be downregulated in the branchial arches. Sox8, Sox9 and Sox10 are co-expressed in the otic vesicle at this stage (arrows). Ventral views (right panels) showing colocalization of Sox8 and Sox9 in the pancreatic rudiments (arrowheads) where Sox10 is not detected. Image published in: O'Donnell M et al. (2006) Copyright © 2006. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue sox8.L X. laevis Throughout NF stage 10 ventro-lateral marginal zone ectoderm neuroectoderm sox8.L X. laevis Throughout NF stage 11.5 neuroectoderm neural crest lower blastopore lip sox8.L X. laevis Sometime during NF stage 14 to NF stage 15 neural crest neuroectoderm neuroectoderm outer layer lateral sox9.S cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 14 to NF stage 15 neural crest neuroectoderm sox10.L X. laevis Throughout NF stage 14 to NF stage 15 neural crest neuroectoderm sox8.L X. laevis Throughout NF stage 17 cement gland primordium neural crest neural plate neuroectoderm sox8.L X. laevis Throughout NF stage 21 trunk neural crest cranial neural crest neuroectoderm sox8.L X. laevis Throughout NF stage 25 brain trunk neural crest cranial neural crest hyoid crest mandibular crest branchial crest forebrain anterior neural tube posterior neural tube neural tube otic placode sox9.S cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 25 otic placode cranial neural crest branchial arch mandibular arch hyoid arch optic vesicle second pancreatic bud sox10.L X. laevis Throughout NF stage 25 otic placode trunk neural crest cranial neural crest neural tube pharyngeal arch branchial arch mandibular arch sox8.L X. laevis Throughout NF stage 35 and 36 neural crest dorsal pancreatic bud second pancreatic bud otic vesicle trunk neural crest pharyngeal arch branchial arch brain midbrain hindbrain forebrain olfactory region neuroectoderm sox9.S cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 35 and 36 neural crest otic vesicle dorsal pancreatic bud second pancreatic bud brain cranial neural crest periocular region anterior branchial crest posterior branchial crest forebrain midbrain sox10.L X. laevis Throughout NF stage 35 and 36 otic vesicle branchial arch cranial neural crest pharyngeal arch forebrain neural tube posterior neural tube anterior neural tube sox8.L X. laevis Throughout NF stage 24 neural crest cranial neural crest neural tube anterior branchial crest mandibular crest hyoid crest posterior branchial crest Image source: Published Larger Image Printer Friendly View

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