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XB-IMG-1253

Xenbase Image ID: 1253


Fig. 1. Sox8 expression in neural crest progenitors and their derivatives. (A) Sox8 is first detected at the gastrula stage in a ventrolateral domain around the blastopore. At stage 11.5 (B-D) Sox8 expression around the blastopore persists and additional expression is detected lateral to the neural plate (arrows). Vegetal (A), lateral (B,C; anterior towards right) and dorsal (D; anterior towards the top) views. Comparison of Sox8 (E) Sox9 (F) and Sox10 (G) expression in sibling stage 14/15 embryos illustrates that all three genes are expressed in the presumptive neural crest. Dorsal views, anterior towards the top. (H) Section of a stage 15 embryo illustrates the expression of Sox8 in both the lateral (arrows) and the medial neural crest (arrowheads). At stage 17 (I,J), Sox8 persists in the neural crest region and is also expressed anterior to the neural plate in the prospective cement gland (arrow). As the neural tube closes (K,L), Sox8 is detected in the migrating neural crest cells in the cranial region (arrows), and the premigratory cells in the trunk neural crest (arrowheads). Dorsal view, anterior towards top (I,K); lateral view, anterior towards the left (L); cranial view (J). (M) Comparison of Sox8, Sox9 and Sox10 expression at the tailbud stages. Dorsal views of stage 25 embryos, anterior towards the right. Sox8, Sox9 and Sox10 are co-expressed in the migrating cranial neural crest. Posteriorly, although Sox8 and Sox10 are both expressed in trunk neural crest cells, Sox9 is downregulated in this cell population. At stage 35 (left panels, lateral views), Sox8 is detected in the cranial neural crest similar to Sox9; however, at this stage, Sox10 starts to be downregulated in the branchial arches. Sox8, Sox9 and Sox10 are co-expressed in the otic vesicle at this stage (arrows). Ventral views (right panels) showing colocalization of Sox8 and Sox9 in the pancreatic rudiments (arrowheads) where Sox10 is not detected.

Image published in: O'Donnell M et al. (2006)

Copyright © 2006. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneSynonymsSpeciesStage(s)Tissue
sox8.LX.laevisThroughout NF stage 10ventro-lateral marginal zone
ectoderm
neuroectoderm
sox8.LX.laevisThroughout NF stage 11.5neuroectoderm
neural crest
lower blastopore lip
sox8.LX.laevisSometime during NF stage 14 to NF stage 15neural crest
neuroectoderm
neuroectoderm outer layer
lateral
sox9.Scmd1, sox-9, sra1, cmpd1, sox9-b, sox9-aX.laevisThroughout NF stage 14 to NF stage 15neural crest
neuroectoderm
sox10.LX.laevisThroughout NF stage 14 to NF stage 15neural crest
neuroectoderm
sox8.LX.laevisThroughout NF stage 17cement gland primordium
neural crest
neural plate
neuroectoderm
sox8.LX.laevisThroughout NF stage 21trunk neural crest
cranial neural crest
neuroectoderm
sox8.LX.laevisThroughout NF stage 25brain
trunk neural crest
cranial neural crest
hyoid crest
mandibular crest
branchial crest
forebrain
anterior neural tube
posterior neural tube
neural tube
otic placode
sox9.Scmd1, sox-9, sra1, cmpd1, sox9-b, sox9-aX.laevisThroughout NF stage 25otic placode
cranial neural crest
branchial arch
mandibular arch
hyoid arch
optic vesicle
second pancreatic bud
sox10.LX.laevisThroughout NF stage 25otic placode
trunk neural crest
cranial neural crest
neural tube
pharyngeal arch
branchial arch
mandibular arch
sox8.LX.laevisThroughout NF stage 35 and 36neural crest
dorsal pancreatic bud
second pancreatic bud
otic vesicle
trunk neural crest
pharyngeal arch
branchial arch
brain
midbrain
hindbrain
forebrain
olfactory region
neuroectoderm
sox9.Scmd1, sox-9, sra1, cmpd1, sox9-b, sox9-aX.laevisThroughout NF stage 35 and 36neural crest
otic vesicle
dorsal pancreatic bud
second pancreatic bud
brain
cranial neural crest
periocular region
anterior branchial crest
posterior branchial crest
forebrain
midbrain
sox10.LX.laevisThroughout NF stage 35 and 36otic vesicle
branchial arch
cranial neural crest
pharyngeal arch
forebrain
neural tube
posterior neural tube
anterior neural tube
sox8.LX.laevisThroughout NF stage 24neural crest
cranial neural crest
neural tube
anterior branchial crest
mandibular crest
hyoid crest
posterior branchial crest

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