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Figure 7. Schematic representation of G6PD regulation and downstream effect. DSBs activate ATM, which in turn promotes the interaction between Hsp27 and G6PD. This association leads to increased activity of G6PD and stimulation of the PPP. ATM also regulates glycolysis and PPP at transcriptional level (dashed arrows) through p53-mediated induction of TIGAR. As a consequence of these events, ROS levels are reduced and the dNTP pool is increased, allowing efficient DNA repair and promoting cell survival. Image published in: Cosentino C et al. (2011) Copyright © 2011, European Molecular Biology Organization. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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