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Figure 3. Receptor-channel coupling in β2 ICCRs: response to the agonist isoproterenol.(A) Representative TEVC recordings from Xenopus oocytes expressing each β2 ICCR and TMD0. Membrane potential was −50 mV. Dashed lines indicate the baseline of Ba2+-sensitive currents. (B) Concentration-effect curves for isoproterenol measured in oocytes co-expressing the indicated proteins. Kir6.2ΔC36 is deleted of its last 36 residues to allow surface expression of the channel alone. Values are average of 5–14 measurements. Smooth lines correspond to Hill equations fits with EC50 in parentheses and h = 1.07 for β2-K-62-25 and 1 for β2-K-72-25. Image published in: Caro LN et al. (2011) Caro et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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