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Fig. 3. Evidence for channel block. A: The use-dependency observed for GB was absent for BB and PXN. For GB, the percentage inhibition measure at peak (31 ± 3.1%) was less than that measured during the first application (38 ± 0.8%). For GB, full recovery was not seen until a second application of GB was applied (inset); at 0.3 mM GB, the first 5-HT response was 91 ± 2% of the second 5-HT response. B–D: The inhibition observed following the co-application (i) of each compound was not seen if the same compound was pre-applied before 5-HT (ii and iii). When compounds were pre-applied immediately before 5-HT (iii), no reduction in the 5-HT response was noted. 5-HT = 2 μM. BB = 1 mM, GB = 300 μM, PXN = 30 μM. For each compound, traces are representative of >5 experiments on ≥2 batches of oocytes. Image published in: Thompson AJ et al. (2011) © 2011 Elsevier Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |