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Figure 4. Actions of L-TBA (30 µM) on postsynaptic responses at the CA1 Schaffer collateral-pyramidal neuron synapse of EAAT3 +/+ (A) and EAAT3 −/− (B) mice.Representative whole cell recordings (−60 mV) showing effect of L-TBA on EPSCs evoked by stimulation in stratum radiatum in the presence (A1, B1) and absence (A2, B2) of physiological extracellular Mg2+ (1.2 mM). (C) Summary of data showing EPSC charge transfer increase in slices from EAAT3 (+/+) and (−/−) mice by 30 µM L-TBA in the absence and presence of Mg2+ (n = 5–7 slices; p<0.05). Data normalized to the charge transfer in slices from EAAT3 (+/+) mice. (D) Summary data showing no significant difference in L-TBA concentration-dependence of EPSC charge transfer increase (normalized to control) for EAAT3 +/+ (open squares) and EAAT3 −/− (filled squares) (n = 4). Image published in: Sun W et al. (2011) Sun et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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