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Figure 3. Ca2+ influx through Aβ1−42 pores is voltage dependent and blocked by Zn2+. (A) Amplitudes of SCCaFTs from Aβ1−42 pores plotted as function of membrane potential. Points show mean amplitudes (ΔF/F0) ± 1 SEM from >30 events from 10 different pores. The fitted regression line extrapolates to 0 at about 30 mV. (B) Superimposed records of SCCaFTs recorded from 26 Aβ pore sites at the voltages indicated. (C) Representative traces from three regions of interest showing control records of SCCaFTs induced by Aβ1−42 (top) and records from the same regions 5 min after adding 300 µM Zn2+ to the bathing solution. Image published in: Demuro A et al. (2011) © 2011 Demuro et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |