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Figure 6. Gating kinetics of Aβ1−42 pores. (A) Distribution of mean open durations (SCCaFT durations) among the 2,820 pores. (B) Corresponding distribution of mean closed times (intervals between SCCaFTs). (C) Corresponding distribution of mean open probabilities (Po; measured as proportion of time for which the fluorescence exceeded a threshold level above the baseline). (D) The Po of pores strongly correlates with their calcium permeability. The scatter plot shows the Po of pores as a function of the amplitude (ampl.) of the largest SCCaFT observed from that pore. (A–C) The blue curves are double exponential fits, with decay constants of 5.3 and 16.3 ms (A), 3.8 and 54 s (B), and 0.0017 and 0.0096 s (C). Data are representative of results from three or more image records obtained in each of four oocytes. Image published in: Demuro A et al. (2011) © 2011 Demuro et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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