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Figure 6. State-independent block of BK channels by BP in Rb+ solutions. (A; insets) Time course of raw BK channel currents recorded in 100 µM Ca2+ in the absence (black) and presence (red) of 2 µM BP at the potentials indicated. Calibration: 0.1 nA, 50 msec. (Main) Steady-state current–voltage relation before (■), during (•), and after (□) application of 2 µM BP in Rb+ solutions. (B) Voltage dependence of BK channel activation (■) and fraction of channels not blocked by BP (○) in 100 µM Ca2+. (Inset) BK currents in response to repolarization to −80 mV from +40 mV in the absence (black) and presence (red; average of four records) of 2 µM BP, with the peak current in the BP scaled to match that of the control record. Calibration: 0.2 nA, 10 msec. Image published in: Thompson J and Begenisich T (2012) © 2012 Thompson and Begenisich. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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