XB-IMG-127146
Xenbase Image ID: 127146
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Figure 2. Active site architecture and α–tubulin C-terminal peptide recognition. (a) Conserved interactions in the TTL active site, colored as in Fig. 1a
(b) Nucleotide (ventral) and (c) dorsal views of the TTL molecular surface color-coded for electrostatic potential55 (red, negative; blue, positive, ranging from −7 kBT to 7 kBT) (d) Tyrosination of a 14-residue α–tubulin C-terminal peptide by TTL and structure-guided TTL mutants (N≥2; Supplementary Fig. 3). The 14-residue peptide (VDSVEGEGEEEGEE) serves as an optimal TTL peptide substrate42. Error bars indicate s.e.m. and are frequently smaller than the symbols. Image published in: Szyk A et al. (2011) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View |