Xenbase Image ID: 127151

Figure 7. Model for TTL action. TTL binds to monomeric tubulin and prevents its incorporation into the MT lattice by occluding the longitudinal interface of the tubulin heterodimer (left panel). TTL acts preferentially on the soluble tubulin pool and detyrosination takes place on MTs. This results in an asymmetry in the distribution of Tyr-tubulin within the MT, with tyrosinated tubulin enriched at the growing plus end where it can aid in the recruitment of proteins sensitive to the tubulin tyrosination status such as plus-end tracking proteins (+TIPS) (right panel). Image published in: Szyk A et al. (2011) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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