Xenbase Image ID: 127399

Figure 2. PH1 is critical for K2P channels C-type gating. (A) Amino-acid alignment of the PH1 region of the indicated K2P channels. The GXG selectivity filter sequence is highlighted in grey. (B, C, E, F, H, I) Exemplar recordings of the response of the indicated K2P channels to the external pH (pHo) changes in 2 mM [K+]o solution. Currents were elicited by a voltage ramp from −150 to +50 mV, from a holding potential of −80 mV. (D, G, J) Quantitation of the response of the K2P channels to changes in pHo. Data (mean±s.e., n⩾6, N⩾2) was taken at 0 mV, normalized to activity at pH 9.0, and fitted to the Hill equation. Image published in: Bagriantsev SN et al. (2012) Copyright © 2012, European Molecular Biology Organization. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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