Xenbase Image ID: 127432

Figure 1. Schematic representation of the domain structure of Lin28b and the processing of pre-let-7 by Dicer. (A) Domain structure of XtrLin28a and b and human (h) Lin28b with the molecular weight and amino acid positions indicated. The truncated Lin28 variants used in this study are shown below the corresponding domain representation. (B) Lin28 inhibits the Dicer-mediated pre-let-7 processing by binding to the pre-element (preE). Image published in: Mayr F et al. (2012) © The Author(s) 2012. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View

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