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Figure 4. Dvl works as adaptor of Par1b/Smad4 complex. (a–c) Luciferase assays in MDA-MB-231 cells, showing that overexpression of Dvl3 is unable to stimulate Smad activity in cells depleted of Par1b (a and b). However, overexpression of Par1b can foster BMP-activity even in the absence of Dvl (c). Data are represented as mean and SD (*P<0.05 Student's t-test). (d) co-IP of overexpressed Par1b and Smad4 (pull down with anti-Par1b antibody) from transfected HEK293T cell lysates with and without co-transfected Dvl3. Co-transfection of Dvl3 enhances Par1b-Smad4 protein interaction Image published in: Mamidi A et al. (2012) Copyright © 2012 Macmillan Publishers Limited. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Larger Image Printer Friendly View

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