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Figure 3. ATP inhibition of wild-type and G1401R channels in the absence and presence of Mg2+A and B, KATP currents recorded in response to voltage ramps from −110 to +110 mV in an inside-out patch excised from oocytes expressing wild-type (A) or Kir6.2/SUR1-G1401R (B) channels. The dashed line indicates the zero current level. The bar indicates application of 10 μm ATP. C and D, mean relationships between [ATP] and KATP conductance (G), expressed relative to that in the absence of nucleotide (Gc), for wild-type (•, n= 10), and Kir6.2/SUR1-G1401R (o, n= 8) channels in the absence of Mg2+ (C); or for wild-type (•, n= 8) or Kir6.2/SUR1-G1401R (o, n= 21) currents in the presence of Mg2+ (D). The lines are drawn to eqn (1) with the following parameters. C: wild-type, IC50= 4.7 μm, h= 1.2; G1401R, IC50= 7.3 μm, h= 0.8, a= 0.011. D: wild-type, IC50= 12 μm, h= 1.0; G1401R, IC50= 27 μm, h= 1.1, a= 0.03. Image published in: de Wet H et al. (2012) Image downloaded from an Open Access article in PubMed Central. © 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society Larger Image Printer Friendly View

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